Publication list

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Boeynaems S, Dorone Y, Anca M, Shabardina V, Huang G, Kim G, Sanyal A, Sen N-E, Docampo R, Ruiz-Trillo I, Lasker K, Auburger G, Kabashi E, Gitler AD. Poly(A)-binding protein is an ataxin-2 chaperone that emulsifies biomolecular condensates. BioRxiv 2021.

Lasker K*, Boeynaems S*, Stainton E, Jacquemyn M, Daelemans D, Holehouse A, Gitler AD, Shapiro L. A modular platform for engineering function of natural and synthetic biomolecular condensates. BioRxiv 2021. co-first


Dorone Y*, Boeynaems S*, Jin B, Bossi F, Flores E, Lazarus E, Michiels E, De Decker M, Baatsen P, Holehouse AS, Sukenik S, Gitler AD, Rhee SY. A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation. Cell 2021, vol. 184(16), p. 4284-4298. co-first
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Gabarre S, Vernaillen F, Baatsen P, Vints K Cawthorne C, Boeynaems S, Michiels E, Vandael D, Gunko N, Munck S. A workflow for streamlined acquisition and correlation of serial regions of interest in array tomography. BMC Biology 2021, vol. 19, DOI: 10.1186/s12915-021-01072-7.

Friedman AK, Boeynaems S#, Baker LA#. Synthetic hydrogel mimics of the nuclear pore complex for the study of nucleocytoplasmic transport defects in C9orf72 ALS/FTD. Analytical and Bioanalytical Chemistry 2021, DOI: 10.1007/s00216-021-03478-2. co-corresponding 

Fumagalli F*, Young FL*, Boeynaems S*, De Decker M, Mehta A, Swijsen A, Fazal R, Guo W, Moisse M, Beckers J, Dedeene L, Bhuvaneish TS, Vandoorne T, Madan V, van Blitterswijk M, Raitcheva D, McCampbell A, Poesen K, Gitler AD, Koch P, Vanden Berghe P, Thal DR, Verfaillie C, Chandran S, Van Den Bosch L, Bullock S, Van Damme P. C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility. Science Advances 2021, vol. 7(15), eabg3013. co-first

Fazal R, Boeynaems S, Swijsen A, De Decker M, Fumagalli L, Moisse M, Vanneste J, Guo W, Boon R, Vercruysse T, Eggermont K, Swinnen B, Beckers J, Pakravan D, Vandoorne T, Vanden Berghe P, Verfaillie CM, Van Damme P. HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations. The EMBO Journal, vol. 40, e106177.

Hasting RL and Boeynaems S#. Designer condensates: a toolkit for the biomolecular architect. Journal of Molecular Biology 2021, vol. 433(12), 166837. corresponding
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Tazelaar GHP*, Boeynaems S*, De Decker M*, van Vugt JJFA, Kool L, Goedee HS, McLaughlin RL, Sproviero W, Iacoangeli A, Moisse M, Jacquemyn M, Daelemans D, Dekker AM, van der Spek RA, Westeneng HJ, Kenna KP, Assialioui A, Da Silva N, Project MinE ALS Sequencing Consortium, Povedano M, Mora Pardina JS, Hardiman O, Salachas F, Millecamps S, Vourc’h P, Corcia P, Couratier P, Morrison KE, Shaw PJ, Shaw CE, Pasterkamp RJ, Landers JE, Van Den Bosch L, Robberecht W, Al-Chalabi A, van den Berg LH, Van Damme P, Veldink JH, van Es MA. ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization. Brain Communications, fcaa064. co-first

Gittings L, Boeynaems S, Lightwood D, Clargo A, Topia S, Nakayama L, Troakes C, Mann D, Gitler AD, Lashley T, Isaacs A. Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity. Acta Neuropathologica, vol. 139, p. 407–410.


Vanneste J, Vercruysse T, Boeynaems S, Sicart A, Van Damme P, Daelemans D, Van Den Bosch L. C9orf72-generated poly-GR and poly-PR do not directly interfere with nucleocytoplasmic transport. Scientific Reports, vol. 9, article number: 15728.

Boeynaems S and Gitler AD. Axons Gonna Ride 'til They Can't No More. Neuron, vol. 104(2), p. 179-181.

Boeynaems S, Holehouse AS, Weinhardt V, Kovacs D, Van Lindt J, Larabell C, Van Den Bosch L, Das R, Tompa P, Pappu RV, Gitler AD. Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties. PNAS, vol. 116(16), p. 7889-7898. co-corresponding


Boeynaems S and Gitler AD. Pour Some Sugar on TDP (-43). Molecular Cell, vol. 71(5), p. 649-651.

Bogaert E*, Boeynaems S*, Kato M, Guo L, Caulfield TR, Steyaert S, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz S, Rousseau F, Shorter J, Callaerts P, Robberecht W, Van Damme P, Van Den Bosch L. Molecular dissection of FUS points at synergistic effect of low-complexity domains in toxicity. Cell Reports, vol. 24(3), p. 529-537. co-first, co-corresponding
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Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa T, Fuxreiter M. Protein phase separation: a new phase in cell biology. Trends in Cell Biology, vol. 28(6), p. 420–435. co-corresponding
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Boeynaems S and Gitler AD. Phosphorylation Leads the Way for Protein Aggregate Disassembly. Developmental Cell , vol. 45(3), p. 279-281.

Swinnen B, Boeynaems S, Schrooten M, Saegeman V, Claeys KG, Van Damme P. Anterior interosseous mononeuropathy associated with HEV infection. Neurology - Neuroimmunology Neuroinflammation, vol. 5(2), e429.

Swinnen B, Bento-Abreu A, Gendron TF, Boeynaems S, Bogaert E, Nuyts R, Timmers M, Scheveneels W, Hersmus N, Wang J, Mizielinska S, Isaacs A, Petrucelli L, Van Damme P, Van Den Bosch L, Robberecht W. A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism. Acta Neuropathologica, vol. 135(3), p. 427–443.

Boeynaems S, Tompa P, Van Den Bosch L. Phasing in on the cell cycle. Cell Division, vol. 13(1). corresponding


Boeynaems S, De Decker M, Tompa P, Van Den Bosch L. Arginine-rich Peptides Can Actively Mediate Liquid-liquid Phase Separation. Bio-protocol, vol. 7(17).

Boeynaems S
, Bogaert E, Kovacs D, Konijnenberg A, Timmerman E, Volkov A, Guharoy M, De Decker M, Jaspers T, Ryan VH, Janke AM, Baatsen P, Vercruysse T, Kolaitis RM, Daelemans D, Taylor JP, Kedersha N, Anderson P, Impens F, Sobott F, Schymkowitz J, Rousseau F, Fawzi NL, Robberecht W, Van Damme P, Tompa P, Van Den Bosch L. Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics. Molecular Cell, vol. 65(6), p. 1044-1055.
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Boeynaems S, Bogaert E, Van Damme P, Van Den Bosch L. Inside out: the role of nucleocytoplasmic transport in ALS and FTLD. Acta Neuropathologica, vol. 132(2), p. 159-173. co-corresponding

Boeynaems S*, Bogaert E*, Michiels E, Gijselinck I, Sieben A, Jovicic A, De Baets G, Scheveneels W, Steyaert J, Cuijt I, Verstrepen KJ, Callaerts P, Rousseau F, Schymkowitz J, Cruts M, Van Broeckhoven C, Van Damme P, Gitler AD, Robberecht W, Van Den Bosch L. Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD. Scientific Reports, vol. 6, article number: 20877.


Jovicic A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada SB, Paul JW 3rd, Sun S, Herdy JR, Bieri G, Kramer NJ, Gage FH, Van Den Bosch L, Robberecht W, Gitler AD. Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. Nature Neuroscience, vol. 18(9), p. 1226-1229.

Gemayel R, Chavali S, Pougach K, Legendre M, Zhu B, Boeynaems S, van der Zande E, Gevaert K, Rousseau F, Schymkowitz J, Babu MM, Verstrepen KJ. Variable glutamine-rich repeats modulate transcription factor activity. Molecular Cell, vol. 59(4), p. 615-627. 


Gemayel R, Cho J, Boeynaems S, Verstrepen KJ. Beyond junk - variable tandem repeats as facilitators of rapid evolution of regulatory and coding sequences. Genes, vol. 3(3), p. 461-480.